Cetylpyridinium chloride (CPC) is a cationic surfactant with strong bactericidal properties and resistance to fungi. It is used as an antibacterial agent in toothpaste, mouthwash, pre-moistened wipes, throat lozenges, and other personal care products that value safety. Recently, it has been popular in pharmaceuticals, cosmetics, toiletries, and industrial use. It is also associated with concerns like neurotoxicity, endocrine disruption, and non-reproductive organ system toxicity.
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Potential skin, eye, and oral mucosal irritation.
Avoid using more than one oral care cosmetic product with Cetylpyridinium Chloride at the same time. Avoid using oral and skin cosmetic products with Cetylpyridinium Chloride simultaneously.
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Unacceptable
Cetylpyridinium chloride is restricted in cosmetics in Japan due to concentration limits. It is also prohibited for use in food. Aggregate exposure to cetylpyridinium chloride via cosmetic products and other consumer products (denture adhesive and cleanser) for the oral and dermal applications may be of concern for some consumers. Additionally, aggregate exposure to cetylpyridinium chloride via cosmetic products and via treated poultry is of concern for consumers. Cetylpyridinium chloride is also associated with concerns like neurotoxicity, endocrine disruption, and non-reproductive organ system toxicity. In 2011, data was submitted to the SCCS to demonstrate the safety of Cetylpyridinium Chloride as a preservative in several categories of cosmetic products focusing on oral care products, skin lotions, creams, and anti-perspirant deodorants, with different restrictions. The SCCS issued an Opinion considering all the information submitted by March 25th, 2015, which is still open for comments until May 29th, 2015. If this Opinion will be accepted, Cetylpyridinium Chloride will be a NEW cosmetics PRESERVATIVE to be used in: Mouthwashes and other oral hygiene cosmetic products up to 0.1% concentration, Skin lotions and creams up to 0.2% concentration, Anti-perspirant deodorants up to 0.2% concentration.
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